Advances in Mutagenesis Research

Applied genetic research, genetic toxicology and mutation research investigate the mutagenicity and cancerogenicity of chemicals and other agents. Permanent mutation in genes and chromosomes, can be induced by aplethora of agents, including ionizing and nonionizing radiations, chemicals, and viruses. Among the aspects discused by Advances in Mutagenesis Research are (1) the understanding of the molecular mechanisms leading to mutations, and (2) the prevention of a thoughtless introduction of mutagenic agents into the environment. Contents: Nikolay W. Timofeeff-Ressovsky (1900-1981): An Essay on his Life and Scientific Achievements. – Arylnitrenium Ions and the Genotoxic Potency of Aromatic Amines and Nitro Compounds. – Analysisof Mutagenicity and Chemical Structure in Various Series of Related Compounds. – Formation of 8-Hydroxyguanine by Oxidative DNA Damage, its Repair and its Mutagenic Effects. – Exploring Genetic and Non-Genetic Relationships: The Induction of Micronuclei. – Mechanisms of Induced Mutagenesis by Ultraviolet Light in Escherichia coli. – Polytene Chromosomes in Mutagenesis. Three-Way Differential Stainingof Chromosomes for the Identification of SCEs per Cell Cycle: Fundamentals and Applications. – The Mammalian Centromere: Centromere Separation, Kinetochore Proteins and Aneuploidy. – Chorionic Villi Analysis. – ExploringGenetic and Non-Genetic Relationships: The Induction of Micronuclei.